Detection of CRISPR-mediated genome modifications through altered methylation patterns of CpG islands.
Background – epigenetics The field of epigenetics deals with hereditary changes that do not change the DNA sequence itself. Epigenetic markers determine which genes are activated or silenced in certains cells and tissues, so they influence gene expression. Thus, the basic structure of the DNA remains unchanged. Epigenetic markers are biochemical appendages of DNA. Epigenetics […]