Horizon Scanning

During the horizon scanning process, scientific publications are screened and evaluated to identify and analyze possible environmental effects of new technical developments and their applications in the field of genetic engineering/biotechnology considering the precautionary principle. The results of the horizon scanning are made available to the public in form of short summaries. It is an ongoing collection of current literature that does not claim to be complete and is continuously updated.
The current focus of the horizon scanning process can be found → here and a glossary with explanations of the most important terms can be found  here

Genome-Edited Plants: Opportunities and Challenges for an Anticipatory Detection and Identification Framework

The authors of the study discuss the problem of the traceability of genome-edited plants that contain only small changes in their genome, such as point mutations, small insertions or deletions. The study explains which information is necessary to detect genome-edited plants and to identify products. It also presents sources of information that may contain relevant […]

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Global detection of DNA repair outcomes induced by CRISPR-Cas9.

Aim of the study and some background information The authors have developed an in silico analysis method called PEM-Q, which evaluates data from genome-wide examinations of genome-edited cells in such a way that all changes in the DNA induced by CRISPR/Cas can be detected. This includes both changes to the target sequence and changes to […]

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New plant breeding techniques and their regulatory implications: An opportunity to advance metabolomics approaches

The study discusses the importance of metabolomics techniques for the assessment of plants that have been altered by genome editing techniques. Metabolomics methods make it possible to analyze changes in metabolic products (= metabolites) in cells. Explanation of some biological principles The DNA of higher living beings is located in the cell nucleus and contains […]

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Detection of CRISPR-mediated genome modifications through altered methylation patterns of CpG islands.

Background – epigenetics The field of epigenetics deals with hereditary changes that do not change the DNA sequence itself. Epigenetic markers determine which genes are activated or silenced in certains cells and tissues, so they influence gene expression. Thus, the basic structure of the DNA remains unchanged. Epigenetic markers are biochemical appendages of DNA. Epigenetics […]

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Exosome-mediated horizontal gene transfer occurs in double-strand break repair during genome editing.

Double-strand breaks (DSBs) in DNA occur naturally in every organism (microoorganisms, plants, animals, humans) and are mended by the cell’s own repair mechanisms. The original state before the DNA damage can be restored or the genome can be changed at that particular region, i.e. the introduction of small insertions, deletions or point mutations. In addition […]

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